Ketamine is an FDA-approved, powerful anesthetic that was developed more than 50 years ago. It has not yet been FDA-approved for the treatment of psychiatric disorders and chronic pain, making it an off-label treatment option.
Ketamine has a good safety profile and has been used widely as an anesthetic in emergency medicine and in operating rooms and wound clinics around the world on a daily basis. It is often used for the most fragile patients, including children and the elderly, because of its safe profile.
Since the year 2000, ketamine has been found to be a valuable and highly effective treatment for depression, anxiety, various mood disorders, and certain pain disorders. It works at the receptor level to stimulate and preserve neurons, a key effect that reduces symptoms associated with mood disorders, PTSD, and chronic pain.